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Pharmacokinetics of antipyrine and trimethoprim in pigs with endotoxin‐induced fever
Author(s) -
LADEFOGED OLE
Publication year - 1979
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/j.1365-2885.1979.tb00377.x
Subject(s) - pharmacokinetics , trimethoprim , volume of distribution , pharmacology , absorption (acoustics) , distribution (mathematics) , elimination rate constant , absorption rate , oral administration , medicine , chemistry , antibiotics , chromatography , biochemistry , mathematics , mathematical analysis , physics , acoustics
Oral administration of antipyrine or trimethoprim to normal and endotoxin‐pretreated, febrile pigs resulted in pharmacokinetic parameters which were different in the two groups of pigs. The one‐compartment model with first order absorption rate constant can be used to describe the pharmacokinetics of antipyrine and trimethoprim in normal pigs but cannot satisfactorily describe the plasma concentration versus time data in the febrile pigs. The absorption rate and the elimination rate of antipyrine and trimethoprim are reduced in the febrile pigs whereas the volume of distribution is increased.