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Enhancement of ampicillin bioavailability in pigs
Author(s) -
GALTIER P.,
ALVINERIE M.
Publication year - 1979
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/j.1365-2885.1979.tb00373.x
Subject(s) - ampicillin , bioavailability , probenecid , chemistry , pharmacology , pharmacokinetics , antibiotics , bioequivalence , medicine , biochemistry
Biliary excretion of Na‐ampicillin was studied in 40–50 kg male castrated pigs fitted with a bile duct re‐entrant cannula. There is a low recovery of antibiotic in the bile after an extraduodenal administration. The injection of sodium de‐hydrocholate increased the bioavailability of ampicillin and decreased the volumes of distribution in the drug. The simultaneous administration of probenecid led also to an increased ampicillin bioavailability. The use of such regimes to obtain longer ampicillin dosage intervals is discussed.