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Pharmacokinetics of ampicillin in pigs
Author(s) -
GALTIER P.,
CHARPENTEAU J. L.
Publication year - 1979
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/j.1365-2885.1979.tb00372.x
Subject(s) - pharmacokinetics , ampicillin , compartment (ship) , urinary system , intramuscular injection , plasma concentration , medicine , pharmacology , chemistry , antibiotics , anesthesia , biochemistry , oceanography , geology
Na‐ampicillin was administered by the intravenous or intramuscular route to pigs. Blood concentrations during 4–6 h after administration and tissue distribution were measured. Pharmacokinetic parameters indicated a two‐compartment open model. The biological half‐life was found to be 60 min and four intramuscular injections per day of 10mg/kg B.W. of Na‐ampicillin were required to maintain a minimum plasma concentration of 0.4 μg/ml. Higher levels were found in both the urinary and digestive tract.