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Drug residues in food animals. III. Plasma and tissue kinetics of potassium penicillin G in young cross‐bred swine
Author(s) -
MERCER H. DWIGHT,
TESKE RICHARD H.,
LONG PATRICIA E.,
SIIOWALTER DAVID II.,
BRYANT HENRY H.
Publication year - 1978
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/j.1365-2885.1978.tb00337.x
Subject(s) - penicillin , chemistry , pharmacokinetics , elimination rate constant , kidney , plasma clearance , renal function , volume of distribution , spleen , distribution (mathematics) , potassium , urine , blood plasma , excretion , endocrinology , medicine , antibiotics , biochemistry , mathematical analysis , mathematics , organic chemistry
Twenty‐two young cross‐bred swine were treated either intravenously or orally with potassium penicillin G. The pharmacokinetics of penicillin G were determined in plasma and tissues. The plasma half‐life of penicillin G in swine was found to be 19.45±1.69 min, and the distribution and elimination kinetics were found to fit a classical two‐compartment model. The volume of distribution was found to be 0.53±0.12 1/kg, and the body clearance was found to be 19.06±5.06 ml/min/kg which exceeded the effective renal plasma flow of 16.50±2.73 ml/min/kg, suggesting that the drug was eliminated both by tubular excretion and glomerular filtration. The elimination rate constants (Beta) for the major organs were as follows: muscle, 0.00343 min ‐1 ; lung, 0.0310 min ‐1 ; fat, 0.0394 min ‐1 ; and kidney, 0.0213 min ‐1 , which compared favorably with the elimination rate constant found in plasma (0.0320 min ‐1 ). These values were found to be significantly similar at the level of P < 0.005 in muscle, spleen and fat, and at a level of P < 0.025 in lung tissue. The data indicates that blood plasma would be a satisfactory body fluid for estimating this drug in tissue.