Premium
Tissue distribution of tetraethylammonium (TEA) in dogs and goats
Author(s) -
NEFFDAVIS CAROL A.,
DAVIS LLOYD E.,
POWERS THOMAS E.
Publication year - 1978
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/j.1365-2885.1978.tb00332.x
Subject(s) - tetraethylammonium , tissue distribution , distribution (mathematics) , chemistry , volume of distribution , blood flow , medicine , distribution volume , endocrinology , biology , potassium , pharmacokinetics , mathematical analysis , mathematics , organic chemistry
The tissue distribution of tetraethylammonium (TEA), a highly polar drug which does not undergo biotransformation, was studied in intact and nephrectomized dogs and goats. Values for β, the overall elimination rate constant, were significantly reduced by nephrectomy but species differences were not significant. Values for apparent specific volume of distribution (V' d ) were unexpectedly large and tissue to plasma ratios were 4.0 and 5.0 in the nephrectomized goat and dog, respectively. The distribution of TEA to various tissues followed closely the expected pattern of regional blood flow, although TEA attained concentrations in liver, heart, lungs and viscera in excess of the concentration in the plasma.