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Differences in relationships among sleep apnoea, glucose level, sleep duration and sleepiness between persons with and without type 2 diabetes
Author(s) -
HARADA YUKA,
OGA TORU,
CHIN KAZUO,
TAKEGAMI MISA,
TAKAHASHI KENICHI,
SUMI KENSUKE,
NAKAMURA TAKAYA,
NAKAYAMAASHIDA YUKIYO,
MINAMI ITSUNARI,
HORITA SACHIKO,
OKA YASUNORI,
WAKAMURA TOMOKO,
FUKUHARA SHUNICHI,
MISHIMA MICHIAKI,
KADOTANI HIROSHI
Publication year - 2012
Publication title -
journal of sleep research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.297
H-Index - 117
eISSN - 1365-2869
pISSN - 0962-1105
DOI - 10.1111/j.1365-2869.2012.00997.x
Subject(s) - medicine , diabetes mellitus , body mass index , sleep (system call) , respiratory disturbance index , type 2 diabetes , sleep disorder , waist , polysomnography , endocrinology , apnea , insomnia , psychiatry , computer science , operating system
Summary Obstructive sleep apnoea is common in patients with diabetes. Recently, it was reported that short sleep duration and sleepiness had deleterious effects on glucose metabolism. Thereafter, several reports showed relationships between glucose metabolism and obstructive sleep apnoea, sleep duration or sleepiness. But the interrelationships among those factors based on recent epidemiological data have not been examined. We analysed data on 275 male employees (age, 44 ± 8 years; body mass index, 23.9 ± 3.1 kg m −2 ) who underwent a cross‐sectional health examination in Japan. We measured fasting plasma glucose, sleep duration using a sleep diary and an actigraph for 7 days, and respiratory disturbance index with a type 3 portable monitor for two nights. Fifty‐four subjects (19.6%) had impaired glucose metabolism, with 21 having diabetes. Of those 21 (body mass index, 25.9 ± 3.8 kg m −2 ), 17 (81.0%) had obstructive sleep apnoea (respiratory disturbance index ≥ 5). Regarding the severity of obstructive sleep apnoea, 10, four and three had mild, moderate and severe obstructive sleep apnoea, respectively. The prevalence of obstructive sleep apnoea was greater in those with than without diabetes ( P = 0.037). Multiple regression analyses showed that the respiratory disturbance index independently related to fasting plasma glucose only in the diabetic subjects. In patients with diabetes, after adjustment for age, waist circumference, etc. sleep fragmentation had a greater correlation with fasting plasma glucose than sleep duration, but without significance ( P = 0.10). Because the prevalence of obstructive sleep apnoea is extremely high in patients with diabetes, sufficient sleep duration with treatment for obstructive sleep apnoea, which ameliorates sleep fragmentation, might improve fasting plasma glucose.