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Cortical locations of maximal spindle activity: magnetoencephalography (MEG) study
Author(s) -
GUMENYUK VALENTINA,
ROTH THOMAS,
MORAN JOHN E.,
JEFFERSON CATHERINE,
BOWYER SUSAN M.,
TEPLEY NORMAN,
DRAKE CHRISTOPHER L.
Publication year - 2009
Publication title -
journal of sleep research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.297
H-Index - 117
eISSN - 1365-2869
pISSN - 0962-1105
DOI - 10.1111/j.1365-2869.2008.00717.x
Subject(s) - magnetoencephalography , sleep spindle , electroencephalography , precentral gyrus , polysomnography , neuroscience , cortex (anatomy) , brain activity and meditation , psychology , somatosensory system , sleep (system call) , scalp , electromyography , audiology , anatomy , medicine , slow wave sleep , magnetic resonance imaging , computer science , radiology , operating system
Summary The aim of this study was to determine the main cortical regions related to maximal spindle activity of sleep stage 2 in healthy individual subjects during a brief morning nap using magnetoencephalography (MEG). Eight volunteers (mean age: 26.1 ± 8.7, six women) all right handed, free of any medical psychiatric or sleep disorders were studied. Whole‐head 148‐channel MEG and a conventional polysomnography montage (EEG; C3, C4, O1 and O2 scalp electrodes and EOG, EMG and ECG electrodes) were used for data collection. Sleep MEG/EEG spindles were visually identified during 15 min of stage 2 sleep for each participant. The distribution of brain activity corresponding to each spindle was calculated using a combination of independent component analysis and a current source density technique superimposed upon individual MRIs. The absolute maximum of spindle activation was localized to frontal, temporal and parietal lobes. However, the most common cortical regions for maximal source spindle activity were precentral and/or postcentral areas across all individuals. The present study suggests that maximal spindle activity localized to these two regions may represent a single event for two types of spindle frequency: slow (at 12 Hz) and fast (at 14 Hz) within global thalamocortical coherence.