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Striatal Dopamine D 1 receptors in narcolepsy: A PET study with [ 11 C]NNC 756
Author(s) -
RINNE J. O.,
HUBLIN C.,
PARTINEN M.,
RUOTTINEN H.,
NÅGREN K.,
LEHIKOINEN P.,
RUOTSALAINEN U.,
LAIHINEN A.
Publication year - 1996
Publication title -
journal of sleep research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.297
H-Index - 117
eISSN - 1365-2869
pISSN - 0962-1105
DOI - 10.1111/j.1365-2869.1996.00262.x
Subject(s) - narcolepsy , putamen , caudate nucleus , cerebellum , dopamine , medicine , dopamine receptor d1 , receptor , endocrinology , neuroscience , psychology , chemistry , dopamine receptor , neurology
SUMMARY We investigated dopamine D, receptors in the putamen and caudate nucleus with positron emission tomography in six patients with narcolepsy and five healthy controls using [ 11 C]NNC 756 as ligand. The caudate‐to‐cerebellum and putamen‐to‐cerebellum ratios of [ 11 C]NNC 756 were within normal limits in patients with narcolepsy. No evidence of increased D 1 , receptor binding in narcolepsy was found.