Premium
Arterial hypertension and sleep apnoea: effect of the angiotensin‐converting enzyme (ACE) Inhibitor cilazapril on continuously measured blood pressure during sleep and wakefulness
Author(s) -
GROTE LUDGER,
HEITMANN JÖRG,
PENZEL THOMAS,
CASSEL WERNER,
PLOCH THOMAS,
PETER JORG HERMANN,
WICHERT PETER
Publication year - 1995
Publication title -
journal of sleep research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.297
H-Index - 117
eISSN - 1365-2869
pISSN - 0962-1105
DOI - 10.1111/j.1365-2869.1995.tb00199.x
Subject(s) - cilazapril , blood pressure , respiratory disturbance index , medicine , heart rate , polysomnography , placebo , cardiology , anesthesia , angiotensin converting enzyme , ace inhibitor , mean arterial pressure , apnea , alternative medicine , pathology
SUMMARY Male patients with arterial hypertension and obstructive sleep‐related breathing disorders (mean age 50 y, Body Mass Index (BMI) 32.4 kg m ‐2 , Respiratory Disturbance Index (RDI) 47.2 and systolic/diastolic blood pressure (SBD/DBD) 162/103 mmHg) were examined before and after 8 days of treatment with the long‐acting angiotensin‐converting‐enzyme (ACE) inhibitor cilazapril 2.5 mg vs. placebo in a double‐blind design with parallel groups. Cardiorespiratory polysom‐nography was carried out at night; during daytime wakefulness patients submitted to examinations of physical and mental exertion. Cilazapril reduced the mean pressure during the entire examination period (day and night) by 9.55 (SD±7.13) mmHg, compared to 4.57 (SD ±7.20) mmHg for placebo ( P < 0.006), independently from systematic changes of heart rate ( x = ‐3.3 and ‐3.5 bpm, respectively). During REM sleep, mean arterial pressure was significantly reduced by 8.63 (SD ±10.1) mmHg, compared to a reduction on placebo of 3.17 (SD 9.6) mmHg ( P = 0.023). Under psychometric strain, the mean arterial pressure was reduced by 15.31 (SD ±8.7) mmHg with cilazapril; under placebo medication by 6.19 (SD ±7.3) mmHg ( P < 0.0001). Heart rate was not significantly changed.