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Acute mood improvement after dextroamphetamine and methylphenldate in narcolepsy
Author(s) -
ZWICKER J.,
BRUCK D.,
PARKES J. D.,
BROUGHTON R. J.
Publication year - 1995
Publication title -
journal of sleep research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.297
H-Index - 117
eISSN - 1365-2869
pISSN - 0962-1105
DOI - 10.1111/j.1365-2869.1995.tb00175.x
Subject(s) - stimulant , mood , dextroamphetamine , methylphenidate , psychology , profile of mood states , narcolepsy , feeling , affect (linguistics) , psychiatry , ingestion , somnolence , modafinil , medicine , clinical psychology , amphetamine , adverse effect , attention deficit hyperactivity disorder , dopamine , social psychology , communication , neuroscience
SUMMARY Mood changes following ingestion of dextroamphetamine (D‐AMP) or methylphenidate (MPH) were examined in 40 narcoleptic patients. The Profile of Mood Status (POMS) and eight additional adjectives describing feelings were used to quantify changes in mood before taking stimulant medication and approximately 90 minutes after ingestion of medication. No significant differences were found between the effects of the two stimulants. When the data from D‐AMP and MPH were combined, significantly higher ratings on the POMS factor of Vigour‐Activity and the adjectives of ‘confident’, ‘talkative’ and ‘competitive’ were found. Lower ratings after medication were noted for the POMS factors of Fatigue‐Inertia, Depression‐Dejection and Confusion‐Bewilderment (all P < 0.001). These effects are similar to those previously reported in normal subjects as well as in certain other patient populations. The findings indicate a possible therapeutic role of stimulant medication not only for the treatment of excessive sleepiness but also for improving affect, motor and mental vigour, and aspects of cognition.