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Sleep apnoea in the Prader‐Willi syndrome
Author(s) -
CLIFT S.,
DAHLITZ M.,
PARKES J. D.
Publication year - 1994
Publication title -
journal of sleep research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.297
H-Index - 117
eISSN - 1365-2869
pISSN - 0962-1105
DOI - 10.1111/j.1365-2869.1994.tb00115.x
Subject(s) - epworth sleepiness scale , polysomnography , excessive daytime sleepiness , medicine , sleep (system call) , multiple sleep latency test , continuous positive airway pressure , anesthesia , apnea , psychology , pediatrics , insomnia , obstructive sleep apnea , sleep disorder , psychiatry , operating system , computer science
SUMMARY Seventeen children and young adults with the Prader‐Willi syndrome were investigated. Twelve of 17 subjects had excessive daytime sleepiness as determined by their own or parental report, a high Epworth Sleepiness Scale score or a short mean sleep latency. Night sleep disturbances were reported in seven subjects with snoring, mouth‐breathing, breath‐holding and occasional nocturnal enuresis. Polysomnography showed abnormalities of sleep structure with rapid eye movements without reduction in muscle tone at sleep onset in 12 subjects, and a high respiratory event index with frequent brief apnoeas, particularly in REM sleep, in 16 subjects. Most apnoeas were not accompanied by arousals. Seven subjects, all of whom were obese, were considered to have symptomatic sleep apnoea and were treated with continuous positive airway pressure (CPAP) but this was poorly tolerated in two. Five subjects continued CPAP over a 6‐month period resulting in subjective improvement in excessive daytime sleepiness in 3. Excessive daytime sleepiness occurs in approximately two‐thirds of subjects with the Prader‐Willi syndrome. It is mainly of central origin but obstructive sleep apnoea may increase sleepiness, particularly in obese subjects.