Premium
Treatment of narcolepsy‐cataplexy syndrome with the new selective and reversible MAO‐A inhibitor brofaromine—a pilot study
Author(s) -
HOHAGEN FRITZ,
MAYER GEERT,
MENCHE ARNDT,
RIEMANN DIETER,
VOLK STEPHAN,
MEIEREWERT KARLHEINZ,
BERGER MATHIAS
Publication year - 1993
Publication title -
journal of sleep research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.297
H-Index - 117
eISSN - 1365-2869
pISSN - 0962-1105
DOI - 10.1111/j.1365-2869.1993.tb00096.x
Subject(s) - multiple sleep latency test , narcolepsy , cataplexy , psychology , placebo , anesthesia , vigilance (psychology) , excessive daytime sleepiness , medicine , modafinil , sleep disorder , psychiatry , insomnia , neuroscience , alternative medicine , pathology
SUMMARY Eighteen narcoleptic patients were treated in a single‐blind study with brofaromine, a new selective and reversible MAO‐A‐inhibitor. After a drug‐free period of seven days, brofaromine was administered for two weeks. Patients were treated with 75 mg brofaromine for the first week and with 150 mg brofaromine for the second week of the study. After an adaptation night nocturnal sleep EEGs were recorded under placebo before brofaromine was given, one week later under 75 mg, and another week later under 150 mg brofaromine. Excessive daytime sleepiness (EDS) was evaluated under placebo at the beginning of the study, under 75 mg at the end of the first week, and under 150 mg brofaromine at the end of the second week by means of the Multiple Sleep Latency Test (MSLT) and the Maintenance of Wakefulness Test (MWT). The number of cataplexies was protocolled by the patients. Compared to placebo the administration of 150 mg brofaromine led to a significant increase of sleep latency in the MLST as well as in the MWT. REM sleep was significantly suppressed in the nocturnal sleep EEG, in the MSLT and in the MWT. The number of cataplexies protocolled by the patient was significantly decreased under 150 mg of brofaromine compared to placebo. Improvement of vigilance and cataplexy occurred in dose‐dependent manner. No serious side effects were observed. The results of the present single‐blind study indicate that brofaromine seems to be a well‐tolerated and effective drug for the treatment of excessive daytime sleepiness and cataplexy in narcoleptic patients.