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Effects of ipsapirone, a 5‐HT 1A agonist, on sleep/wakefulness cycles: probable post‐synaptic action
Author(s) -
TISSIER MARIEHÉLÈNE,
LAINEY ERIC,
FATTACCINI CLAUDEMICHELLE,
HAMON MICHEL,
ADRIEN JOËLLE
Publication year - 1993
Publication title -
journal of sleep research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.297
H-Index - 117
eISSN - 1365-2869
pISSN - 0962-1105
DOI - 10.1111/j.1365-2869.1993.tb00070.x
Subject(s) - ipsapirone , wakefulness , agonist , serotonergic , medicine , endocrinology , dorsal raphe nucleus , chemistry , stimulation , anxiolytic , 5 ht1a receptor , neurotoxin , 8 oh dpat , receptor , serotonin , psychology , 5 ht receptor , neuroscience , electroencephalography
SUMMARY The effects of ipsapirone, a ligand of the 5‐HT 1A receptors and a new potential anxiolytic, on sleep/wakefulness regulation were examined in the rat. Injected i.p. at 1, 3 and 5 mg kg ‐1 , this compound induced a dose‐dependent reduction of paradoxical sleep for 2 to 4 hours, followed, at a dose of 5 mg kg ‐1 , by a secondary rebound. The other states of vigilance were not modified, except at the latter dose where the amounts of wakefulness were enhanced initially and decreased secondarily, while those of SWS were enhanced from 2 to 4 hours post‐treatment. The effects of ipsapirone (3 mg kg ‐1 ) persisted after infusion of the neurotoxin 5,7‐dihydroxytryptamine into the dorsal raphe nucleus which induced the sub‐total destruction of the serotoninergic system. Thus, the action of the 5‐HT 1A agonist ipsapirone on sleep/wakefulness cycles probably involves the stimulation of the post‐synaptic 5‐HT 1A receptors.