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Studies on sleep/wake effects of serotonin reuptake inhibitors and receptor subtype involvement
Author(s) -
URSIN R.,
BJORVATN B.,
SOMMERFELT L.,
NECKELMANN D.,
BJØRKUM A. A.
Publication year - 1992
Publication title -
journal of sleep research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.297
H-Index - 117
eISSN - 1365-2869
pISSN - 0962-1105
DOI - 10.1111/j.1365-2869.1992.tb00031.x
Subject(s) - ritanserin , serotonergic , serotonin , antagonist , endocrinology , medicine , psychology , reuptake inhibitor , 5 ht receptor , cats , chemistry , receptor
SUMMARY Studies with the serotonin uptake inhibitors zimeldine and alaproclate show biphasic effects on the sleep/wake axis in rats and cats. Zimeldine induced an initial waking response succeeded by a small SWS‐2 increase in rats. The waking increase was not blocked by the 5‐HT 2 antagonist ritanserin nor by the putative 5‐HT 1A antagonist (‐)‐alprenolol. In cats, zimeldine induced initial behavioural changes which were succeeded by a large SWS‐2 increase. Alaproclate gave similar initial responses as zimeldine in both species, and was succeeded by a moderate sleep increase in cats but not in rats. The complex sleep/wake effects following the serotonin uptake inhibitors may result from simultaneous induction of incompatible serotonergic effects.