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Neurobiological structure of the revised limit cycle reciprocal interaction model of REM cycle control
Author(s) -
McCARLEY R.W.,
MASSAQUOI S.G.
Publication year - 1992
Publication title -
journal of sleep research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.297
H-Index - 117
eISSN - 1365-2869
pISSN - 0962-1105
DOI - 10.1111/j.1365-2869.1992.tb00026.x
Subject(s) - reciprocal , limit cycle , psychology , limit (mathematics) , control (management) , neuroscience , computer science , mathematics , artificial intelligence , mathematical analysis , philosophy , linguistics
SUMMARY New data bearing on the neurobiological basis of REM sleep and on mechanisms of EEG synchronization/desynchronization are presented. The revision of the limit cycle reciprocal interaction model (LCRIM) of REM cycle control incorporates new information on monoamine inhibition of mesopontine cholinergic neurons and of cholinergic mechanisms promoting REM sleep. New data also show cortical slow‐wave activity is controlled by thalamocortical neurons' membrane potential level, which, in turn, is strongly controlled during sleep by brainstem cholinergic input arising from REM‐on neurons. This new knowledge leads to a neurobiologi‐cally justified integration of the LCRIM and of the two‐process model of sleep control.