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Efficacy of alpha lipoic acid in burning mouth syndrome: a randomized, placebo‐treatment study
Author(s) -
LÓPEZJORNET P.,
CAMACHOALONSO F.,
LEONESPINOSA S.
Publication year - 2009
Publication title -
journal of oral rehabilitation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.991
H-Index - 93
eISSN - 1365-2842
pISSN - 0305-182X
DOI - 10.1111/j.1365-2842.2008.01914.x
Subject(s) - placebo , visual analogue scale , medicine , burning mouth syndrome , adverse effect , placebo group , alpha lipoic acid , anesthesia , gastroenterology , oxidative stress , alternative medicine , pathology
Summary To study the efficacy of alpha lipoic acid (ALA) in a group of patients with burning mouth syndrome (BMS). Sixty BMS patients, 30 treated with ALA (Thioderm ® ) 800 mg day −1 for 8 weeks and 30 patients on the same protocol with a placebo. The symptomatology was measured on a Visual Analogue Scale (VAS). Sixty patients (54 females and 6 males, mean age 64·37 ± 11·61 years) were included. Thirty‐nine patients completed the treatment (23 with ALA and 16 with a placebo). Reviews were carried out at 0, 1 and 2 months. No statistically significant differences were found in the average pre‐ and post‐treatment values for pain with the VAS scores, obtained in the placebo (6·6 ± 2·5 − 2·8 ± 25 = 3·8 ± 3·7) versus ALA (6·3 ± 2·8 − 4·0 ± 2·7 = 2·2 ± 2·6). Only one patient pertaining to the group treated with ALA abandoned because of adverse gastrointestinal side effects. The results showed no significant differences between the two groups.