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Feasibility of using collagen as the base of the antifungal drug, miconazole
Author(s) -
YOSHIDA K.,
HIRAI K.,
ARA T.,
ITO M.,
WANG P.L.,
IGARASHI Y.
Publication year - 2006
Publication title -
journal of oral rehabilitation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.991
H-Index - 93
eISSN - 1365-2842
pISSN - 0305-182X
DOI - 10.1111/j.1365-2842.2005.01568.x
Subject(s) - miconazole , candida albicans , antifungal drug , miconazole nitrate , chemistry , antifungal , corpus albicans , minimum inhibitory concentration , chromatography , nuclear chemistry , pharmacology , microbiology and biotechnology , in vitro , biochemistry , medicine , biology
summary The feasibility of using collagen as the base of miconazole was investigated. The addition of 33% collagen to a miconazole solution did not affect the minimal inhibitory concentration (MIC 80 ) of the miconazole solution for Candida albicans . When 1 μ g mL −1 of miconazole in 33% collagen solution was plated on resin discs and dried to yield a thin membrane, the growth of C. albicans on the resin discs was nearly completely inhibited. In addition, we compared the antifungal effect of this collagen solution that contained 1 μ g mL −1 miconazole, with the antifungal effect of miconazole gel that had been diluted with glycerol (the main component of miconazole gel) to yield a final concentration of 1 μ g mL −1 of miconazole; as a result, we found that the collagen solution containing 1 μ g mL −1 miconazole had a stronger antifungal effect. In conclusion, our results demonstrated that it may be feasible to use collagen as the base of miconazole instead of glycerol, and suggest that a collagen‐based miconazole solution would have a stronger antifungal effect than commercially available miconazole gel. Collagen‐based miconazole solution may be useful for the treatment of Candida ‐associated denture stomatitis.