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Safety and antibacterial properties of controlled release SnF 2
Author(s) -
TINANOFF N.,
SIEGRIST B.,
LANG N. P.
Publication year - 1986
Publication title -
journal of oral rehabilitation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.991
H-Index - 93
eISSN - 1365-2842
pISSN - 0305-182X
DOI - 10.1111/j.1365-2842.1986.tb01557.x
Subject(s) - dentistry , molar , streptococcus mutans , irritation , oral hygiene , placebo , medicine , fluoride , saliva , chemistry , bacteria , biology , genetics , inorganic chemistry , alternative medicine , pathology , immunology
Summary Two clinical studies were performed to evaluate the safety and efficacy of an intracoronal device for the controlled release of SnF 2 . SnF 2 ‐polycarboxylate cement, containing approximately 72mgF−, was placed in subjects' molars requiring two‐surface restorations. In the trial for safety, eight subjects had the restoration in place for 34 days. The salivary fluoride levels were elevated to a mean of 0.3/106. over the experimental period. Urinary fluoride levels were only above baseline levels during the first few days. The restoration's physical properties were adequate; however, subjects experienced gingival irritation in areas where the restoration was contacted with gingiva. In the trial for efficacy, fourteen subjects had either a SnF 2 ‐polycarboxylate or a placebo restoration placed in a molar tooth during a 2 week period of no oral hygiene. During the experimental period, the control subjects had higher levels of salivary total CFU, Streptococcus sanguis and Streptococcus mutans: while the subjects with the SnF2 restoration had increased S. sanguis and decreased S. mutans levels. No differences in G.I. or PL 1 scores were noted between groups. Further development of this controlled release system should include using the SnF 2 ‐polycarboxylate restoration in more than one tooth per subject to increase the fluoride reservoir, and not allowing the restoration to contact gingival tissues.