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Oestradiol Regulates β‐Catenin‐Mediated Transcription in Neurones
Author(s) -
Wandosell F.,
Varea O.,
Arevalo M. A.,
GarciaSegura L. M.
Publication year - 2012
Publication title -
journal of neuroendocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.062
H-Index - 116
eISSN - 1365-2826
pISSN - 0953-8194
DOI - 10.1111/j.1365-2826.2011.02186.x
Subject(s) - wnt signaling pathway , gsk 3 , microbiology and biotechnology , catenin , signal transduction , biology , medicine , protein kinase b , endocrinology , transcription factor , hedgehog signaling pathway , chemistry , gene , genetics
Oestradiol acts in the brain by multiple mechanisms, including the regulation of transcriptional activity through classical oestrogen receptors, α and β, and by the activation of membrane/cytoplasm‐initiated signalling cascades. In neuroblastoma cells, primary neurones in culture and in the brain in vivo , oestradiol activates the phosphoinositide 3‐kinase/Akt/glycogen synthase kinase 3 signalling pathway by a mechanism involving oestrogen receptor α. Through this pathway, oestradiol regulates the stability of β‐catenin, induces the translocation of β‐catenin to the cell nucleus and regulates β‐catenin‐mediated transcription through the T cell factor/DNA complex. Genomic analyses in neuroblastoma cells have revealed that the set of genes regulated by oestradiol through β‐catenin is not identical to that regulated by the Wnt signalling pathway, revealing a new mechanism for oestradiol signalling in neurones.