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Neurokinin B Signalling in Human Puberty
Author(s) -
Topaloglu A. K.,
Kotan L. D.,
Yuksel B.
Publication year - 2010
Publication title -
journal of neuroendocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.062
H-Index - 116
eISSN - 1365-2826
pISSN - 0953-8194
DOI - 10.1111/j.1365-2826.2010.02013.x
Subject(s) - endocrinology , medicine , kisspeptin , signalling , neurokinin b , biology , neuropeptide , receptor , hypothalamus , microbiology and biotechnology , substance p
Recent identification of TAC3 or TACR3 (encoding neurokinin B and its receptor, NK3R, respectively) mutations as the causes of normosmic idiopathic hypogonadotrophic hypogonadism has provided compelling evidence for the involvement of neurokinin B (NKB) signalling in puberty. A surge of subsequent studies pointing towards an understanding of the exact mechanism through which NKB signalling exerts its effects in puberty led to a postulated sketch of the GnRH pulse generator, in which kisspeptin, NKB and dynorphin work in concert to elicit pulsatile gonadotrophin‐releasing hormone release in the median eminence.