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Nuclear Receptor Coactivators: Essential Players for Steroid Hormone Action in the Brain and in Behaviour
Author(s) -
Tetel M. J.
Publication year - 2009
Publication title -
journal of neuroendocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.062
H-Index - 116
eISSN - 1365-2826
pISSN - 0953-8194
DOI - 10.1111/j.1365-2826.2009.01827.x
Subject(s) - nuclear receptor , transactivation , hormone , steroid , steroid hormone , receptor , endocrinology , medicine , nuclear receptor coactivator 1 , estrogen related receptor gamma , biology , transcription factor , hormone receptor , nuclear receptor coactivator 3 , biochemistry , gene , cancer , breast cancer
Steroid hormones act both in the brain and throughout the body to influence behaviour and physiology. Many of these effects of steroid hormones are elicited by transcriptional events mediated by their respective receptors. A variety of cell culture studies reveal that nuclear receptor coactivators are critical for modulating steroid receptor‐dependent transcription. Thus, in addition to the availability of the hormone and the expression of its receptor, nuclear receptor coactivators are essential for steroid‐dependent transactivation of genes. This review discusses the mounting evidence indicating that nuclear receptor coactivators are critical for modulating steroid hormone action in the brain and in the regulation of behaviour.