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Endocannabinoids and the Neurochemistry of Gluttony
Author(s) -
Kirkham Tim
Publication year - 2008
Publication title -
journal of neuroendocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.062
H-Index - 116
eISSN - 1365-2826
pISSN - 0953-8194
DOI - 10.1111/j.1365-2826.2008.01762.x
Subject(s) - endocannabinoid system , endocrinology , medicine , cannabinoid receptor , neurochemistry , appetite , adipose tissue , cannabinoid , receptor , chemistry , psychology , neuroscience , agonist , neurology
Summary Cannabis exerts its actions by mimicking ‘endocannabinoid’ neuromodulators at CB1 receptors in brain and peripheral tissues. The endocannabinoids both stimulate appetite by increasing food craving and enjoyment and promote the deposition of energy as fat in adipose tissues. These findings have raised the possibility of CB1 antagonists as a novel class of anti‐obesity agents.