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Kisspeptin and GPR54: Discovery of a Novel Pathway in Reproduction
Author(s) -
Seminara S. B.,
Crowley Jr W. F.
Publication year - 2008
Publication title -
journal of neuroendocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.062
H-Index - 116
eISSN - 1365-2826
pISSN - 0953-8194
DOI - 10.1111/j.1365-2826.2008.01731.x
Subject(s) - hypogonadotrophic hypogonadism , kisspeptin , context (archaeology) , endocrinology , medicine , receptor , biology , hypogonadotropic hypogonadism , secretion , reproduction , hormone , g protein coupled receptor , genetics , paleontology
In order to find novel modulators of gonadotrophin‐releasing hormone (GnRH) secretion, genetic tools were employed in patients with idiopathic hypogonadotrophic hypogonadism (IHH). Mutations in a G‐protein coupled receptor, GPR54, were identified, making this receptor a genetic determinant and indisputable gatekeeper of normal reproductive function. This article places these investigations into historical context and reviews some of the new findings relevant to this pathway.