Premium Kisspeptin and GPR54: Discovery of a Novel Pathway in ReproductionPremium
Author(s)
Seminara S. B.,
Crowley Jr W. F.
Publication year2008
Publication title
journal of neuroendocrinology
Resource typeJournals
PublisherBlackwell Publishing Ltd
In order to find novel modulators of gonadotrophin‐releasing hormone (GnRH) secretion, genetic tools were employed in patients with idiopathic hypogonadotrophic hypogonadism (IHH). Mutations in a G‐protein coupled receptor, GPR54, were identified, making this receptor a genetic determinant and indisputable gatekeeper of normal reproductive function. This article places these investigations into historical context and reviews some of the new findings relevant to this pathway.
Subject(s)biology , context (archaeology) , endocrinology , g protein coupled receptor , genetics , hormone , hypogonadotrophic hypogonadism , hypogonadotropic hypogonadism , kisspeptin , medicine , paleontology , receptor , reproduction , secretion
Language(s)English
SCImago Journal Rank1.062
H-Index116
eISSN1365-2826
pISSN0953-8194
DOI10.1111/j.1365-2826.2008.01731.x
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