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Endogenous Cannabinoids: Structure and Metabolism
Author(s) -
Bisogno T.
Publication year - 2008
Publication title -
journal of neuroendocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.062
H-Index - 116
eISSN - 1365-2826
pISSN - 0953-8194
DOI - 10.1111/j.1365-2826.2008.01676.x
Subject(s) - endocannabinoid system , delta 9 tetrahydrocannabinol , cannabis sativa , cannabinoid , cannabis , endogeny , lipid metabolism , metabolism , cannabinoid receptor , pharmacology , biology , neuroscience , endocrinology , biochemistry , chemistry , medicine , receptor , psychiatry , botany , agonist
The finding of specific binding sites for Δ 9 ‐tetrahydrocannabinol, the psychoactive component of Cannabis sativa , has led to the discovery of the endocannabinoid system and has emphasised the physiological and pathological relevance of endocannabidoid lipid signalling. Subsequently, an increasing number of papers have been published on the biochemistry and pharmacology of endocannabinoids. An overview of the current understanding of structure and metabolism of the best studied endocannabinoids is provided, with a focus on the mechanisms responsible for their biosynthesis and inactivation.