Premium
Elevated KiSS‐1 Expression in the Arcuate Nucleus Prior to the Cyclic Preovulatory Gonadotrophin‐Releasing Hormone/Lutenising Hormone Surge in the Ewe Suggests a Stimulatory Role for Kisspeptin in Oestrogen‐Positive Feedback
Author(s) -
Estrada K. M.,
Clay C. M.,
Pompolo S.,
Smith J. T.,
Clarke I. J.
Publication year - 2006
Publication title -
journal of neuroendocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.062
H-Index - 116
eISSN - 1365-2826
pISSN - 0953-8194
DOI - 10.1111/j.1365-2826.2006.01485.x
Subject(s) - kisspeptin , endocrinology , medicine , arcuate nucleus , arc (geometry) , gonadotropin releasing hormone , luteinizing hormone , estrous cycle , hormone , biology , chemistry , geometry , mathematics
Kisspeptins are encoded by the gene KiSS‐1 and regulate gonadotrophin‐releasing hormone (GnRH) and gonadotrophin secretion in various species, including humans. Here, we quantify gene expression of KiSS‐1 in the arcuate nucleus (ARC) across the ovine oestrous cycle and demonstrate an increase in the caudal division of the ARC during the preovulatory period. These data strongly suggest that kisspeptins are involved in the generation of the preovulatory GnRH and luteinising hormone surge.