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Cell Biology of the Ghrelin Receptor
Author(s) -
Camiña J. P.
Publication year - 2006
Publication title -
journal of neuroendocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.062
H-Index - 116
eISSN - 1365-2826
pISSN - 0953-8194
DOI - 10.1111/j.1365-2826.2005.01379.x
Subject(s) - ghrelin , growth hormone secretagogue receptor , receptor , endocrinology , medicine , energy homeostasis , secretagogue , enteroendocrine cell , endocrine system , hypothalamus , biology , endogeny , hormone , chemistry
Ghrelin, a gastric peptide involved in growth hormone release and energy homeostasis, is the endogenous ligand of the growth hormone secretagogue receptor type 1a (GHS‐R1a), a G‐protein coupled receptor mainly expressed in the pituitary and hypothalamus. This receptor mediates the main ghrelin‐stimulated endocrine actions and some of the nonendocrine actions. However, a number of nonendocrine actions associated with ghrelin appear to be mediated by various GHS‐R1a‐related receptor subtypes, which are widely distributed in the central and peripheral tissues. This review summarises data concerning the localisation, regulation and function of GHS‐R1a, as well as related receptors.