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A Role for the Mineralocorticoid Receptor in a Rapid and Transient Suppression of Hippocampal 5‐HT 1A Receptor mRNA by Corticosterone
Author(s) -
Meijer Onno C.,
Kloet E. Ronald
Publication year - 1995
Publication title -
journal of neuroendocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.062
H-Index - 116
eISSN - 1365-2826
pISSN - 0953-8194
DOI - 10.1111/j.1365-2826.1995.tb00804.x
Subject(s) - endocrinology , mineralocorticoid receptor , medicine , corticosterone , mineralocorticoid , hippocampal formation , receptor , messenger rna , aldosterone , chemistry , biology , hormone , biochemistry , gene
The interaction between corticosterone and hippocampal 5‐HT 1A receptor mRNA expression was investigated in male rats. Two days after adrenalectomy, 5‐HT 1A receptor mRNA was increased in the granule cell layer of the dentate gyrus. Injection of corticosterone led to a significant dose‐dependent and transient suppression of 5‐HT 1A receptor mRNA. The effect of a low dose of corticosterone (50 μg/kg) could be blocked by RU 28318, a specific mineralocorticoid receptor antagonist, but not by RU 38486, a glucocorticoid antagonist. The effect of a higher dose of corticosterone (300 μg/kg) could be partially blocked by RU 28318, whereas there was no additional effect of RU 38486. These results point to a stringent regulation of hippocampal 5‐HT 1A receptors by corticosterone that is predominantly mediated by the mineralocorticoid receptor.