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Central Glucopenia Induced by 2‐Deoxy‐D‐Glucose Stimulates Somatostatin Secretion in the Rat
Author(s) -
Sato Makoto,
Murao Koji,
Matsubara Shuji,
Niimi Michio,
Chihara Kazuo,
Takahara Jiro
Publication year - 1995
Publication title -
journal of neuroendocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.062
H-Index - 116
eISSN - 1365-2826
pISSN - 0953-8194
DOI - 10.1111/j.1365-2826.1995.tb00717.x
Subject(s) - medicine , endocrinology , somatostatin , secretion , pulsatile flow , chemistry , antiserum , peptide hormone , hypothalamus , growth hormone , hormone , biology , antibody , immunology
The mechanisms involved in 2‐deoxy‐D‐glucose (2‐DG)‐induced growth hormone (GH) suppression in the rat were examined. Conscious male rats were given 2‐DG by intracerebroventricular (icv) injection and the pulsatile GH secretion was monitored for 6 h. The single icv injection of 2‐DG (8 mg/rat) eliminated pulsatile GH secretion in conscious rats. Pretreatment with somatostatin (SS) antiserum completely restored the suppressed GH secretion in the 2‐DG treated rats. Hypothalamic GH‐releasing hormone (GRH) and SS mRNA levels were not altered by single and multiple icv injections of 2‐DG. These findings suggest that 2‐DG‐induced GH suppression is primarily due to hypersecretion of SS without a significant change at the transcription level in the rat.