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Proopiomelanocortin, Preproenkephalin‐A and Preprocholecystokinin mRNA in the Hypothalamus of CCI 4 ‐Treated Rats
Author(s) -
Brini Anna,
Morghen Carlo,
Bianchi Mauro,
Rovati Lucio C.,
Panerai Alberto E.
Publication year - 1989
Publication title -
journal of neuroendocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.062
H-Index - 116
eISSN - 1365-2826
pISSN - 0953-8194
DOI - 10.1111/j.1365-2826.1989.tb00109.x
Subject(s) - proopiomelanocortin , endocrinology , medicine , hypothalamus , cholecystokinin , messenger rna , chemistry , biology , receptor , gene , biochemistry
It has previously been shown that β‐endorphin (BE) and cholecystokinin (CCK) concentrations decrease in brain areas of rats or humans affected by severe liver disease (SLD). We now report the increase of proopiomelanocortin (POMC) and preprocholecystokinin mRNA in the hypothalamus and cortex of rats with experimental SLD, suggesting an increased post‐translational turnover of BE and CCK in this experimental condition.