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Levels of Transcripts Encoding a Member of the Protein Kinase C Family in the Paraventricular and Supraoptic Nuclei are Increased by Hyperosmolality
Author(s) -
Young W. Scott
Publication year - 1989
Publication title -
journal of neuroendocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.062
H-Index - 116
eISSN - 1365-2826
pISSN - 0953-8194
DOI - 10.1111/j.1365-2826.1989.tb00083.x
Subject(s) - protein kinase c , medicine , supraoptic nucleus , endocrinology , in situ hybridization , messenger rna , chemistry , gene , biology , kinase , hypothalamus , microbiology and biotechnology , biochemistry
The distribution of mRNA transcripts for the six known protein kinase C (PKC) genes has been investigated by quantitative in situ hybridization histochemistry. PKC‐δ transcripts were detected only in the thalamus and PKC‐ζ was found in several areas including the supraoptic (SON) and paraventricular (PVN) nuclei. Activation of magnocellular cells in the SON and PVN following 7 days of saline‐loading resulted in increased levels of PKC‐ζ transcripts in both of these nuclei.