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Corticotrophin‐Releasing Factor Antagonist [alpha helical CRF(9–41)] Blocks Central Noradrenaline‐lnduced ACTH Secretion
Author(s) -
Takao Toshihiro,
Hashimoto Kozo,
Hirasawa Ryuto,
Makino Shinya,
Sugawara Masanori,
Murakami Kazuharu,
Ota Zensuke
Publication year - 1989
Publication title -
journal of neuroendocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.062
H-Index - 116
eISSN - 1365-2826
pISSN - 0953-8194
DOI - 10.1111/j.1365-2826.1989.tb00082.x
Subject(s) - endocrinology , medicine , secretion , antagonist , acth secretion , endogeny , alpha (finance) , chemistry , receptor , adrenocorticotropic hormone , hormone , construct validity , nursing , patient satisfaction
Plasma ACTH increased after an intra‐third ventricular administration of noradrenaline (NA). An iv corticotrophin‐releasing factor (CRF) antagonist [alpha‐helical CRF(9–41)] injection did not affect ACTH secretion by itself, whereas it significantly reduced NA‐induced ACTH secretion. These results suggest that NA centrally stimulated ACTH secretion and that endogenous CRF is involved in this ACTH secretion.