Premium
Particle size analysis: 90 Y and 99m Tc‐labelled colloids
Author(s) -
JANKOVIĆ D.,
MAKSIN T.,
DJOKIĆ D.,
MILONJIĆ S.,
NIKOLIĆ N.,
MIRKOVIĆ M.,
VRANJEŠDJURIĆ S.
Publication year - 2008
Publication title -
journal of microscopy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.569
H-Index - 111
eISSN - 1365-2818
pISSN - 0022-2720
DOI - 10.1111/j.1365-2818.2008.02124.x
Subject(s) - colloid , particle size , transmission electron microscopy , analytical chemistry (journal) , antimony , tin , materials science , particle (ecology) , spectroscopy , chemistry , crystallography , nanotechnology , physics , chromatography , metallurgy , oceanography , quantum mechanics , geology
Summary Colloidal particle size is an important characteristic to consider when choosing a radiopharmaceutical for diagnosis and therapeutic purposes in nuclear medicine. Photon correlation spectroscopy (PCS) and transmission electron microscopy (TEM) were used to determine the particle‐size distribution of 90 Y‐ and 99m Tc‐labelled antimony trisulfide (Sb 2 S 3 ) and tin colloids (Sn‐colloid). 90 Y‐Sb 2 S 3 and 99m Tc‐Sb 2 S 3 were found to have a diameter of 28.92 ± 0.14 and 35.61 ± 0.11 nm, respectively, by PCS. By TEM, 90 Y‐Sb 2 S 3 particles were measured to be 14.33 ± 0.09 nm. 90 Y‐labelled Sn colloid were found to exist with a d v(max1) of 805 nm and a d v(max2) of 2590 nm, by PCS, whereas 99m Tc‐Sn colloid was shown to have more than 80% of radioactive particles of approximately 910 nm by PCS. For 90 Y‐labelled Sb 2 S 3 and Sn colloid, a comparison of TEM and PCS indicates that these techniques found significantly different mean diameters. TEM has an excellent resolution necessary for radiocolloid particle‐sizing analysis, and it is a desirable size‐measuring technique because it is more reliable than PCS.