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Regulation of macrophage adhesion and migration by Rho GTP‐binding proteins
Author(s) -
RIDLEY A.J.
Publication year - 2008
Publication title -
journal of microscopy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.569
H-Index - 111
eISSN - 1365-2818
pISSN - 0022-2720
DOI - 10.1111/j.1365-2818.2008.02064.x
Subject(s) - adhesion , microbiology and biotechnology , cell migration , cell adhesion , cytoskeleton , macrophage , focal adhesion , chemistry , rac gtp binding proteins , actin cytoskeleton , actin , cell , gtp' , biology , biochemistry , signal transduction , in vitro , enzyme , organic chemistry
Summary The Rho family proteins Rac and Rho are believed to be key regulators of cell migration through their effects on the cytoskeleton and cell adhesion. However, recent studies in macrophages indicate that they are not always essential for migration, although they do affect cell shape and adhesion.