Premium
Mechanisms of actin stress fibre assembly
Author(s) -
NAUMANEN P.,
LAPPALAINEN P.,
HOTULAINEN P.
Publication year - 2008
Publication title -
journal of microscopy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.569
H-Index - 111
eISSN - 1365-2818
pISSN - 0022-2720
DOI - 10.1111/j.1365-2818.2008.02057.x
Subject(s) - actin , myosin , focal adhesion , morphogenesis , stress fiber , biophysics , stress (linguistics) , protein filament , motility , microbiology and biotechnology , anatomy , chemistry , materials science , biology , composite material , biochemistry , gene , linguistics , phosphorylation , philosophy
Summary Stress fibres are contractile acto‐myosin structures found from many types of non‐muscle cells, where they are involved in adhesion, motility and morphogenesis. Stress fibres typically display a periodic α‐actinin–myosin II pattern and are thus suggested to resemble the sarcomeric actin filament structures of muscle cells. Mammalian cells contain three categories of stress fibres: ventral stress fibres that are attached to focal adhesions at both ends, dorsal stress fibres that are attached to focal adhesions typically at one end and transverse arcs that are curved acto‐myosin bundles, which do not directly attach to focal adhesions. In this review, we discuss the definition of stress fibres, organization of actin filaments and other components within these contractile structures, and the mechanisms of stress fibre assembly.