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Insights into the regulation of transcription by scanning force microscopy
Author(s) -
Dame R. T.,
Wyman C.,
Goosen N.
Publication year - 2003
Publication title -
journal of microscopy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.569
H-Index - 111
eISSN - 1365-2818
pISSN - 0022-2720
DOI - 10.1111/j.1365-2818.2003.01243.x
Subject(s) - scanning force microscopy , transcription (linguistics) , computational biology , transcription factor , microbiology and biotechnology , microscopy , nanotechnology , atomic force microscopy , biology , biophysics , computer science , materials science , genetics , physics , gene , optics , philosophy , linguistics
Summary The scanning force microscope (SFM) is a valuable tool for the structural analysis of complexes between protein(s) and DNA. In recent years the application of scanning force microscopy to the field of transcription regulation has been reported in numerous studies. Using this technique, novel insights could be obtained into the architecture and dynamics of complexes, which are relevant to the transcription process and the mechanisms by which this process is regulated. In this article an overview is given of SFM studies addressing, in particular, topics in the field of transcription in prokaryotic organisms.