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Light microscope based analysis of three‐dimensional structure: Applications to the study of Drosophila salivary gland nuclei. II. Algorithms for model analysis
Author(s) -
Mathog David
Publication year - 1985
Publication title -
journal of microscopy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.569
H-Index - 111
eISSN - 1365-2818
pISSN - 0022-2720
DOI - 10.1111/j.1365-2818.1985.tb02583.x
Subject(s) - polytene chromosome , salivary gland , drosophila (subgenus) , algorithm , computer science , computational biology , biology , chromosome , genetics , biochemistry , gene
SUMMARY In Drosophila melanogater there are significant differences in the way the polytene chromosomes are arranged in different nuclei from the same salivary gland (Mathog et al. , 1984). Visual inspection of the models of these nuclei was inadequate to delineate all of the features conserved in their structures. In order to bypass this limitation, models of these nuclei were constructed in a format compatible with computational manipulation (Mathog et al. , 1985). By applying some simple algorithms to these models, quantitative comparisons were made which revealed otherwise cryptic features common to many nuclei. Given here are the details of several algorithms for describing and comparing the arrangement of the chromosomes within the nuclei.