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Quantitative studies of the autofluorescence derived from neuronal lipofuscin
Author(s) -
Dowson J. H.,
Harris S. J.
Publication year - 1981
Publication title -
journal of microscopy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.569
H-Index - 111
eISSN - 1365-2818
pISSN - 0022-2720
DOI - 10.1111/j.1365-2818.1981.tb02469.x
Subject(s) - lipofuscin , autofluorescence , chemistry , neuroscience , pathology , biology , biochemistry , medicine , fluorescence , optics , physics
SUMMARY The degree of accumulation of neuronal lipofuscin in the human brain can indicate the age of some neurones, may be correlated with certain disease processes and can be affected by drugs. The estimation of the volume of neuronal lipofuscin has usually employed relatively unreliable methods such as counting techniques or visual ratings, while the present paper describes and illustrates a method for measuring the intensity of the autofluorescence derived from neuronal lipofuscin. The relationship between autofluorescence intensity and amount of lipofuscin is discussed.