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Interactions of uranyl ions with lipid bilayer membranes
Author(s) -
TingBeall H. P.
Publication year - 1980
Publication title -
journal of microscopy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.569
H-Index - 111
eISSN - 1365-2818
pISSN - 0022-2720
DOI - 10.1111/j.1365-2818.1980.tb00264.x
Subject(s) - uranyl , chemistry , membrane , uranyl acetate , ion , phospholipid , dissociation (chemistry) , dissociation constant , lipid bilayer , bilayer , inorganic chemistry , phosphate , organic chemistry , biochemistry , receptor , medicine , staining , pathology
SUMMARY Uranyl ions (UO 2 2+ ), once bound to the phosphate moieties of phospholipid head groups, stabilize bimolecular lipid membranes (BLMs) as well as decrease the nonactin‐induced membrane conductance. UO 2 2+ bind to a phosphatidyl choline‐cholesterol (2:1, molar ratio) BLM surface with a dissociation constant of 2·3 μM and a maximum change in surface potential of 88 mV, which corresponds approximately to one uranyl ion per 31 nm 2 surface area. Furthermore, uranyl ions can penetrate the lipid bilayers as neutral complexes such as uranyl acetate.