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Quantitative analysis of micrographs by computer graphics *
Author(s) -
Dunn Robert F.,
O'Leary Dennis P.,
Kumley Warren E.
Publication year - 1975
Publication title -
journal of microscopy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.569
H-Index - 111
eISSN - 1365-2818
pISSN - 0022-2720
DOI - 10.1111/j.1365-2818.1975.tb04051.x
Subject(s) - axon , computer graphics , position (finance) , computer science , graphics , computation , bundle , myelin sheath , myelin , computer graphics (images) , artificial intelligence , biological system , anatomy , materials science , neuroscience , algorithm , biology , finance , economics , composite material , central nervous system
SUMMARY A computer‐aided graphical analysis system is presented which can be used to quantify several types of information from micrographs of cross‐sectioned peripheral nerves. A simple input consisting of eight points, corresponding to two diameters of each axon and two for each axon plus myelin, is used to compute statistical and numerical estimates of these diameters, the myelin thickness being expressed as a function of axon diameter, and both the spatial position and distribution of nerve fibres within the bundle. The computer programs presented and summarized here describe the procedure for digitizing the input data and the subsequent computations for editing and analysis. The general applicability of this approach for automated analyses of other anatomical areas is also presented.