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The dimensions and numbers of small vesicles in blood capillary endothelium in the hind legs of dogs, and their relation to vascular permeability
Author(s) -
CasleySmith J. R.,
Clark Helen I.
Publication year - 1972
Publication title -
journal of microscopy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.569
H-Index - 111
eISSN - 1365-2818
pISSN - 0022-2720
DOI - 10.1111/j.1365-2818.1972.tb04663.x
Subject(s) - vesicle , vascular permeability , capillary action , endothelium , biophysics , chemistry , permeability (electromagnetism) , anatomy , membrane , biology , physics , endocrinology , biochemistry , thermodynamics
SUMMARY The dimensions and numbers of vesicles were determined in the blood capillary endothelium of the gastrocnemii muscle of dogs. These results permitted more accurate calculations of the number of vesicles crossing the endothelium in one direction/sec/(μm 2 (∼6·2), and of the median vesicular attachment time (∼8 sec). The probability of fusion occurring when a vesicle contacts a plasma membrane (α= 0·004) was unchanged: hence it was concluded, from the mean cellular width (0·21 μm) and the calculated cytoplasmic viscosity (∼0·1 poise), that ∼49% of the vesicles starting from one side reached the other one, and that their median transit time was ∼1 sec.