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Certain effects of histamine and of pilocarpine upon the granules of the oxyntico‐peptic cells of Gallus domesticus
Author(s) -
MENZIES GORDON
Publication year - 1965
Publication title -
journal of the royal microscopical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.569
H-Index - 111
eISSN - 1365-2818
pISSN - 0368-3974
DOI - 10.1111/j.1365-2818.1965.tb02144.x
Subject(s) - histamine , nucleus , pilocarpine , chemistry , granule (geology) , nucleolus , anatomy , biology , endocrinology , microbiology and biotechnology , neuroscience , paleontology , epilepsy
SYNOPSIS New observations are presented on the oxyntico‐peptic cells of Gallus domesticus . In the control animals (which were starved for 72 hours) acid phosphatase is present below the nucleus in the cytoplasm of the majority of the cells lying in the upper part of the alveoli. Following the administration of histamine, there is an increase of acid phosphatase. In cells situated in the upper part of the alveoli it is present above and alongside the nucleus. In many cells lying in the lower part of the alveoli it occurs chiefly in an infranuclear position, although in some it is above and alongside the nucleus. There is a progressive decrease in the number of pepsinogen granules, and in cells in many areas of the mucosa, this is preceded by a progressive decrease in the intensity of colouring of the granules. Evacuation of the granules commences in cells lying in the lower part of the alveoli and proceeds to those that are situated in the upper part of the alveoli. The larger type of granule is discharged first, and 2 to 3 hours after injection of the drug all the granules have been discharged from the cells. It seems probable that the pepsinogen granules reappear in cells found in the basal half of the alveoli about 6 hours after histamine injection. Following the injection of pilocarpine, very large spheroids which stain an intense blue after Bowie's method are found above the nucleus in cells lying in the upper part of the alveoli.