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V ‐REACTIONS TO IMPLANTATION OF METHYLCHOLANTHRENE SOAKED SILK THREAD INTO KIDNEYS AND ADRENALS OF EXPERIMENTAL ANIMALS
Author(s) -
Hirtzler Raoul
Publication year - 1958
Publication title -
journal of the royal microscopical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.569
H-Index - 111
eISSN - 1365-2818
pISSN - 0368-3974
DOI - 10.1111/j.1365-2818.1958.tb02041.x
Subject(s) - sarcoma , carcinogen , connective tissue , pathology , methylcholanthrene , renal pelvis , epithelium , kidney , medicine , biology , genetics
SYNOPSIS Silk threads dipped in molten methylcholanthrene were implanted into kidneys of mice, hamsters, and rats, as well as into adrenals of hamsters and rats. One sarcoma and one carcinoma developed in kidneys of mice after a latency of 6 months. It is very likely that the sarcoma originated from the connective tissue which incapsulated the thread, and the carcinoma from the epithelium of the renal pelvis. No tumours were produced in rats and hamsters 6 months after the beginning of the experiment, probably because of a too short observation. Rats are not suitable for such experiments because of their prominent fibrous reaction, so that tumours, if any could be induced, would very likely be sarcomata. Hamsters react with very slight or no fibrosis, especially in the adrenals, so that there is a possibility of direct contact of the carcinogen and the epithelium. They are therefore suitable for implantation experiments, but the observation should last more than 6 months, or another carcinogen with shorter latency should be chosen.