Premium
THE STRUCTURE AND PROGRESSION OP VESICAL TUMOURS INDUCED IN MICE BY 2‐ACETYLAMINOPLUORENE
Author(s) -
Foulds L.
Publication year - 1950
Publication title -
journal of the royal microscopical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.569
H-Index - 111
eISSN - 1365-2818
pISSN - 0368-3974
DOI - 10.1111/j.1365-2818.1950.tb04423.x
Subject(s) - pathology , papilloma , biology , transplantation , carcinoma in situ , tumor progression , carcinoma , medicine , cancer , genetics
SYNOPSIS. Nine vesical tumours induced in mice by 2‐acetylaminofluorene were studied histologically and three were transplanted in series. Four tumours were invasive and two of them had disseminated in the peritoneal cavity. Histologically the tumours ranged from squamous‐ or transitional‐celled papillomata to spindle‐ or pleomorphic‐celled tumours without distinctively epithelial characters. For reasons which are discussed, the origin of all the varied tumour cells is traced to the transitional epithelium of the bladder. Different tumours represent different stages in one neoplastic process leading, as a result of irreversible qualitative changes or “progression” in the tumour cells, from localized papilloma to disseminating undifferentiated carcinoma, a sequence observed during serial transplantation of one tumour. Progression does not always reach its end‐point in a primary tumour. It continues in transplanted tumours in normal mice and independently of the inciting carcinogen. Progression is focal in occurrence. Alternative paths of progression lead to different end‐points.