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Increased age, high body mass index and low HDL‐C levels are related to an echolucent carotid intima–media: the METEOR study
Author(s) -
Peters S. A. E.,
Lind L.,
Palmer M. K.,
Grobbee D. E.,
Crouse J. R,
O’Leary D. H.,
Evans G. W.,
Raichlen J.,
Bots M. L.,
den Ruijter H. M.
Publication year - 2012
Publication title -
journal of internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.625
H-Index - 160
eISSN - 1365-2796
pISSN - 0954-6820
DOI - 10.1111/j.1365-2796.2011.02505.x
Subject(s) - medicine , body mass index , rosuvastatin , cardiology , intima media thickness , echogenicity , surgery , carotid arteries , ultrasonography
. Peters SAE, Lind L, Palmer MK, Grobbee DE, Crouse JR III, O’Leary DH, Evans GW, Raichlen J, Bots ML, den Ruijter HM, on behalf of the METEOR study group (University Medical Center Utrecht, Utrecht, The Netherlands; Uppsala University Hospital, Uppsala, Sweden; Keele University, Keele, UK; Wake Forest University School of Medicine, Winston‐Salem, NC, USA; Caritas Carney Hospital, Boston, MA, USA; and AstraZeneca, Wilmington, DE, USA). Increased age, high body mass index and low HDL‐C levels are related to an echolucent carotid intima–media: the METEOR study. J Intern Med 2012; 272: 257–266. Introduction. Echolucent plaques are related to a higher cardiovascular risk. Studies to investigate the relationship between echolucency and cardiovascular risk in the early stages of atherosclerosis are limited. We studied the relationship between cardiovascular risk factors and echolucency of the carotid intima–media in low‐risk individuals. Methods. Data were analysed from the Measuring Effects on Intima‐Media Thickness: an Evaluation of Rosuvastatin (METEOR) study, a randomized placebo‐controlled trial including 984 individuals which showed that rosuvastatin attenuated the rate of change of carotid intima–media thickness (CIMT). In this post hoc analysis, duplicate baseline ultrasound images from the far wall of the left and right common carotid arteries were used for the evaluation of the echolucency of the carotid intima–media, measured by grey‐scale median (GSM) on a scale of 0–256. Low GSM values reflect echolucent, whereas high values reflect echogenic structures. The relationship between baseline GSM and cardiovascular risk factors was evaluated using linear regression models. Results. Mean baseline GSM (± SD) was 84 ± 29. Lower GSM of the carotid intima–media was associated with older age, high body mass index (BMI) and low levels of high‐density lipoprotein cholesterol (HDL‐C) [beta −4.49, 95% confidence interval (CI) −6.50 to −2.49; beta −4.51, 95% CI −6.43 to −2.60; beta 2.45, 95% CI 0.47 to 4.42, respectively]. Common CIMT was inversely related to GSM of the carotid intima–media (beta −3.94, 95% CI −1.98 to −5.89). Conclusion. Older age, high BMI and low levels of HDL‐C are related to echolucency of the carotid intima–media. Hence, echolucency of the carotid intima–media may be used as a marker of cardiovascular risk profile to provide more information than thickness alone.