Premium
The genetics of ischaemic stroke
Author(s) -
Matarin M.,
Singleton A.,
Hardy J.,
Meschia J.
Publication year - 2010
Publication title -
journal of internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.625
H-Index - 160
eISSN - 1365-2796
pISSN - 0954-6820
DOI - 10.1111/j.1365-2796.2009.02202.x
Subject(s) - medicine , ischaemic stroke , genome wide association study , stroke (engine) , neurogenetics , genetic association , etiology , medical genetics , neurology , genetics , bioinformatics , gene , single nucleotide polymorphism , genotype , psychiatry , biology , disease , ischemia , mechanical engineering , engineering
. Matarin M, Singleton A, Hardy J, Meschia J (Laboratory of Neurogenetics, Bethesda, MD, USA; UCL Institute of Neurology, London, UK; Mayo Clinic, Jacksonville, FL, USA). The genetics of ischaemic stroke (Review). J Intern Med 2010; 267: 139–155. In this review, we discuss the genetic factors in both the aetiology and treatment of ischaemic stroke. We discuss candidate gene association studies, family linkage studies and the more recent whole genome association studies and whole genome expression studies. We also briefly discuss genetic testing for stroke risk and genetic analysis of treatment complications.