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Gender difference of association between LDL cholesterol concentrations and mortality from coronary heart disease amongst Japanese: the Ibaraki Prefectural Health Study
Author(s) -
Noda H.,
Iso H.,
Irie F.,
Sairenchi T.,
Ohtaka E.,
Ohta H.
Publication year - 2010
Publication title -
journal of internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.625
H-Index - 160
eISSN - 1365-2796
pISSN - 0954-6820
DOI - 10.1111/j.1365-2796.2009.02183.x
Subject(s) - medicine , hazard ratio , coronary heart disease , population , cholesterol , risk factor , prospective cohort study , cohort , cardiology , demography , confidence interval , environmental health , sociology
. Noda H, Iso H, Irie F, Sairenchi T, Ohtaka E, Ohta H (Osaka University, Osaka, Japan; Harvard School of Public Health, Cambridge, MA, USA; Ibaraki Prefectural Office, Ibaraki; Dokkyo Medical University School of Medicine, Tochigi; Ibaraki Health Service Association, Ibaraki; Japan). Gender difference of association between LDL cholesterol concentrations and mortality from coronary heart disease amongst Japanese: the Ibaraki Prefectural Health Study. J Intern Med 2010; 267 :576–587. Objective. The aim of this study was to examine whether LDL cholesterol raises the risk of coronary heart disease in a dose–response fashion in a population with low LDL‐cholesterol levels. Design. Population‐based prospective cohort study in Japan. Subjects and main outcome measures. A total of 30 802 men and 60 417 women, aged 40 to 79 years with no history of stroke or coronary heart disease, completed a baseline risk factor survey in 1993. Systematic mortality surveillance was performed through 2003 and 539 coronary heart disease deaths were identified. Results. The mean values for LDL‐cholesterol were 110.5 mg dL −1 (2.86 mmol L −1 ) for men and 123.9 mg dL −1 (3.20 mmol L −1 ) for women. Men with LDL‐cholesterol ≥140 mg dL −1 (≥3.62 mmol L −1 ) had two‐fold higher age‐adjusted risk of mortality from coronary heart disease than did those with LDL‐cholesterol <80 mg dL −1 (<2.06 mmol L −1 ), whereas no such association for women was found. The multivariable hazard ratio for the highest versus lowest categories of LDL‐cholesterol was 2.06 (95 percent confidence interval: 1.34 to 3.17) for men and 1.16 (0.64 to 2.12) for women. Conclusion. Higher concentrations of LDL‐cholesterol were associated with an increased risk of mortality from coronary heart disease for men, but not for women, in a low cholesterol population.