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Infectious agents and lymphoma development: molecular and clinical aspects
Author(s) -
Ferreri A. J. M.,
Ernberg I.,
CopieBergman C.
Publication year - 2009
Publication title -
journal of internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.625
H-Index - 160
eISSN - 1365-2796
pISSN - 0954-6820
DOI - 10.1111/j.1365-2796.2009.02083.x
Subject(s) - malt lymphoma , marginal zone , medicine , lymphoma , borrelia burgdorferi , helicobacter pylori , mucosa associated lymphoid tissue , immunology , lymphatic system , lymphoproliferative disorders , virus , borrelia , pathology , virology , b cell , antibody
. This review is focused on the role of infectious agents in the development of some lymphoma entities. Associations involving bacterial infections mostly regard marginal zone B‐cell lymphomas of mucosa‐associated lymphoid tissue (MALT)‐type. Some paradigmatic examples of these associations include the Helicobacter pylori ‐related gastric MALT lymphoma and the more recently reported links between Chlamydophila psittaci and ocular adnexal MALT lymphomas and Borrelia burgdorferi and cutaneous MALT lymphomas. The well‐documented association between Epstein–Barr virus infection and related lymphoproliferative disorders are analysed as an example of lymphotropic virus with tumourigenic activity. Molecular, biological and clinical features as well as therapeutic implications of these associations are analysed and future perspectives in this field are discussed.