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Autoimmune and inflammatory disorders and risk of malignant lymphomas – an update
Author(s) -
Smedby K. E.,
Askling J.,
Mariette X.,
Baecklund E.
Publication year - 2008
Publication title -
journal of internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.625
H-Index - 160
eISSN - 1365-2796
pISSN - 0954-6820
DOI - 10.1111/j.1365-2796.2008.02029.x
Subject(s) - medicine , lymphoma , autoimmunity , inflammation , immunology , risk factor , pathology , immune system
. As specific autoimmune disorders now constitute established risk factors for malignant lymphomas, we describe this association. We review reported risk levels, risk determinants, lymphoma subtypes and biological mechanisms in autoimmunity/inflammation, emphasizing on recent findings. Whilst numerous reports describe average lymphoma risks in large patient groups, there’s a recent shift of focus to risk determinants and the role of inflammatory activity. Studies highlight associations with diffuse large B‐cell lymphoma, apart from lymphoma development in target organs of inflammation. Future studies of high‐risk patient subsets using detailed assessments of autoimmunity/inflammation and lymphoma may give important clues to lymphomagenesis.