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Regulatory T‐cell immunity and its relevance to atherosclerosis
Author(s) -
Taleb S.,
Tedgui A.,
Mallat Z.
Publication year - 2008
Publication title -
journal of internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.625
H-Index - 160
eISSN - 1365-2796
pISSN - 0954-6820
DOI - 10.1111/j.1365-2796.2008.01944.x
Subject(s) - medicine , immunology , context (archaeology) , immune system , disease , acquired immune system , inflammation , innate immune system , immunity , t cell , biology , pathology , paleontology
. Atherosclerosis is a chronic inflammatory disease of the arterial wall where both innate and adaptive immune responses contribute to disease initiation and progression. Recent studies from several groups suggest that subtypes of T cells, called regulatory T cells, previously shown to maintain immunological tolerance, inhibit the development and progression of atherosclerosis. Here, we review the current knowledge on the regulatory T‐cell response and the major cytokines involved in its modulation in the context of atherosclerosis.