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SIRT6 in DNA repair, metabolism and ageing
Author(s) -
Lombard D. B.,
Schwer B.,
Alt F. W.,
Mostoslavsky R.
Publication year - 2008
Publication title -
journal of internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.625
H-Index - 160
eISSN - 1365-2796
pISSN - 0954-6820
DOI - 10.1111/j.1365-2796.2007.01902.x
Subject(s) - sirt6 , sirtuin , ageing , longevity , dna repair , model organism , biology , saccharomyces cerevisiae , dna damage , microbiology and biotechnology , genetics , function (biology) , yeast , dna , gene , acetylation
. Ageing, or increased mortality with time, coupled with physiologic decline, is a nearly universal yet poorly understood biological phenomenon. Studies in model organisms suggest that two conserved pathways modulate longevity: DNA damage repair and Insulin/Igf1‐like signalling. In addition, homologs of yeast Sir2 – the sirtuins – regulate lifespan in diverse organisms. Here, we focus on one particular sirtuin, SIRT6. Mice lacking SIRT6 develop a degenerative disorder that in some respects mimics models of accelerated ageing [ Cell (2006) 124 :315]. We discuss how sirtuins in general and SIRT6 specifically relate to other evolutionarily conserved pathways affecting ageing, and how SIRT6 might function to ensure organismal homeostasis and normal lifespan.